3Rs	Replacement, Reduction and Refinement
AAT	Alternative Animal Testing
AChE	acetylcholinesterase
ADME	Absorption, Distribution, Metabolism and Excretion
AE	Assessment Entities
AFSA	Animal-Free Safety Assessment
AI	Artificial Intelligence
AO	Adverse Outcome
AOP	Adverse Outcome Pathway
AREC	Act on Registration and Evaluation of Chemicals
ATSDR	Agency for Toxic Substances and Disease Registry
BER	Bioactivity Exposure Ratio
BPB	Bisphenol B
BPR	Biocidal Products Regulation (Regulation (EU) 528/2012)
BPS	Bisphenol S
CFSA	China National Center for Food Safety Risk Assessment
CLP	Classification, Labelling and Packaging of Substances and Mixtures (Regulation (EC) No 1272/2008)
CMR	Carcinogen, Mutagen or Reprotoxic
CMP	Chemicals Management Plan
CPSC	U.S. Consumer Product Safety Commission
CRO	contract research organisation
CTD	Clothianidin
DA	Defined Approach
DAPRM	Data Acquisition and Processing Reporting Modules
DG ENV	EC Directorate-General for Environment
DILI	drug induced liver injury
DNEL	Derived No Effect Level
DNT	Developmental Neurotoxicity
DoD	Department of Defense
DOI	Digital Object Identifier
EC	European Commission
ECETOC	European Centre for Ecotoxicology and Toxicology of Chemicals
ECHA	European Chemicals Agency
ECOSAR	Ecological Structure Activity Relationships
ECVAM	European Centre for the Validation of Alternative Methods
ED	Endocrine Disruptor
EFSA	European Food Safety Authority
EOGRTS	Extended One-Generation Reproductive Toxicity Study
ER	Estrogen Receptor
ERTA	Estrogen Receptor Transactivation
EMA	European Medicines Agency
EURL ECVAM	EU Reference Laboratory for alternatives to animal testing
EUROoCS FAIR	European Organ-on-Chip Society Findable, Accessible, Interoperable, Reusable
FAO	Food and Agriculture Organisation
FDA	Food and Drug Administration
FNT	Fenitrothion
FSA	Food Standards Agency
GD	Guidance Document
GIVIMP	Guidance Document on Good In Vitro Method Practices
GLP	Good Laboratory Practice
GRAP	Good Read-Across Practice
HC HECSB	Healthy Environments and Consumer Safety Branch of Health Canada
HC PMRA	Health Canada Pest Management Regulatory Agency
HLC	Human Lethal Concentration
IATA	Integrated Approaches to Testing and Assessment
ICCR	International Cooperation on Cosmetics Regulation
ICCS	International Collaboration on Cosmetics Safety
ICCVAM	Interagency Coordinating Committee on the Validation of Alternative Methods
ICH	International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
ILSI	International Life Sciences Institute
IPCS	International Programme on Chemical Safety
IQ-DILI	International Consortium for Innovation and Quality in Pharmaceutical Development - Drug Induced Liver Injury
ISTAND	Innovative Science and Technology Approaches for New Drugs
IVIVE	In Vitro to In Vivo Extrapolation
JaCVAM	Japanese Center for the Validation of Alternative Methods
JECFA	Joint FAO/WHO Expert Committee on Food Additives
JMPR	FAO/WHO Joint Meeting on Pesticide Residues
JRC	Joint Research Centre
KE	Key Event
KFDA	Ministry of Food and Drug Safety of the Republic of Korea
KoCVAM	Korean Center for the Validation of Alternative Methods
MIE	Molecular Initiating Events
ML	Machine Learning
MoA	Mode (or Mechanism) of Action
MOE	Ministry of Environment of the Republic of Korea
MPS	microphysiological systems
NAM	New Approach Methodology
NCATS	National Center for Advancing Translational Sciences
NCEA	National Center for Environmental Assessment
NGRA	Next Generation Risk Assessment
NICETAM	NTP Interagency Center for the Evaluation of Alternative Toxicological Methods
NIH	National Institutes of Health
NLM	National Library of Medicine
NOAEL	No Observed Adverse Effect Level
NTP	National Toxicology Program
OECD	Organisation for Economic Co-operation and Development
OoC	Organ-on-a-chip
ORD	Office of Research and Development
OPP	Office of Pesticide Programs
OPPT	Office of Pollution Prevention and Toxics
PARC	Partnership for the Assessment of Risks from Chemicals
PBBK	Physiological Based Biokinetic
PBK	Physiologically Based Kinetic
PBPK	Physiologically-based Pharmacokinetic
PBT	Persistent, Bioaccumulative and Toxic
PBTK	Physiologically Based Toxicokinetic
PFAS	Per- and polyfluoroalkyl substances
PFOA	Perfluorooctanoic acid
PMN	PreManufacture Notification
PoD	Point of Departure
PPP	Plant Protection Products (Regulation (EC) No 1107/2009)
QI	Quality Improvement
QIVIVE	Quantitative In Vitro to In Vivo Extrapolation
QSAR	Quantitative Structure Activity Relationship
RAAF	Read-Across Assessment Framework
RAWG	Read-Across Workgroup
REACH	Registration, Evaluation, Authorisation and Restriction of Chemicals (Regulation (EC) No 1907/2006)
RSS	Robust Study Summary
RxA	Read Across
SAR	Structure Activity Relationship
SCCS	Scientific Community on Consumer Safety
SCHC	Society for Chemical Hazard Communication
SME	Small and Medium-sized Enterprises
SOP	Standard Operating Procedures
SSbD	Safe and Sustainable by Design
SSRM	Study Summary Reporting Module
SVHC TERM	Substances of Very High Concern Toxicology Experiment Reporting Module
TG	Test Guideline
TRL	Technology Readiness Level
TSAR	Tracking System for Alternative methods towards Regulatory acceptance
TSCA	Toxic Substances Control Act
TTC	Threshold of Toxicological Concern
UVCB	Unknown or Variable composition, Complex reaction products or of Biological materials
vPvB	very Persistent and very Bioaccumulative
WHO	World Health Organisation
WoE	Weight of Evidence
ZEN	Zearalenone