Tool / Database	Link	Description
AOP-Wiki	https://aopwiki.org/	Adverse Outcome Pathway Wiki
AOP knowledge base (AOP-KB)	https://aopkb.oecd.org/	Sharepoint for AOPs launched by the OECD. It combines evidence from multiple locations namely the AOP-Wiki, Effectopedia, AOP Xplorer and Intermediate Effects DB.
BLAST	https://blast.ncbi.nlm.nih.gov/Blast.cgi#:~:text=The%20Basic%20Local%20Alignment%20Search,the%20statistical%20significance%20of%20matches.	In silico tool for sequence similarity searching between biological sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance
Blood Exposome Database	https://bloodexposome.org/	Database of endogenous and exogenous chemicals associated with the mammalian circulating system.
Chemical Mixture Calculator	www.chemicalmixturecalculator.dk	tool for mixture risk assessment Discussed in: https://doi.org/10.1016/j.fct.2021.112167
ComptoxAI	https://comptox.ai/	Data infrastructure for computational and artificial intelligence research in predictive toxicology
ConsExpo	https://www.rivm.nl/en/consexpo	Tool to model the exposure to chemical substances from everyday consumer products.
COSMOS	http://www.cosmostox.eu/what/COSMOSdb/	Knowledge hub to share toxicity data and in silico tools. Discussed in: https://doi.org/10.1016/j.comtox.2021.100175
DB-ALM	https://norecopa.no/3r-guide/db-alm-database-on-alternative-methods	Database of Alternative Methods summaries and protocols (EURL ECVAM DataBase)
DevTox	https://www.devtox.org/index_en.php	Examples for external, skeletal, visceral and maternal-fetal anomalies
ExpoBOX (EPA)	https://www.epa.gov/expobox	Compendium of exposure assessment tools that links to guidance documents, databases, models, reference materials, and other related resources
FASTA	https://www.ebi.ac.uk/jdispatcher/sss/fasta	In silico tool for sequence similarity searching against protein databases
Human Metabolome Database (HMDB)	https://hmdb.ca/	Database containing detailed information about small molecule metabolites found in the human body.
Integrated Chemical Environment (ICE)	https://ice.ntp.niehs.nih.gov/	Open-access computational support tools for PBK modeling and IVIVE
IndusChemFate	https://cefic-lri.org/toolbox/induschemfate/	PBTK model currently being developed by Cefic LRI in collaboration with IndusTox Consult as part of the project HBM2 Discussed in: https://doi.org/10.1016/j.yrtph.2022.105267
JRC QSAR Model Database	https://data.jrc.ec.europa.eu/dataset/e4ef8d13-d743-4524-a6eb-80e18b58cba4	Archive providing information on the validity of Quantitative Structure-Activity Relationship (QSAR) models
MetaboLights	https://www.ebi.ac.uk/metabolights/	Database for Metabolomics experiments and derived information. It covers metabolite structures and their reference spectra as well as their biological roles and locations.
Omim	https://www.omim.org/	Online Catalog of Human Genes and Genetic Disorders
OpenFoodTox	https://www.efsa.europa.eu/en/data-report/chemical-hazards-database-openfoodtox	Open source toxicological database, available both for download and data visualisation which provides data for all substances evaluated by EFSA including substance characterisation, links to EFSA's outputs, applicable legislations regulations, and a summary of hazard identification and hazard characterisation data for human health, animal health and ecological assessments.
PACEM	https://www.rivm.nl/en/consumer-exposure-to-chemical-substances/exposure-models/Pacem	Tool to model the exposure to chemical substances from everyday consumer products.
Pred-skin	http://predskin.labmol.com.br/	The Pred-Skin application is based on externally predictive QSAR models of skin sensitisation
QIVIVE tool	www.qivivetools.wur.nl	Web-based toolbox that contains generic physiologically based kinetic (PBK) models for rats and humans, including underlying calculation tools to predict plasma protein binding and tissue:plasma distribution, to be used for quantitative in-vitro-to-in-vivo extrapolations (QIVIVE)
QSAR Model Reporting Format (QMRF)	https://qmrf.sourceforge.net/	The QSAR Model Reporting Format (QMRF) is a harmonised template for summarising and reporting key information on QSAR models, including the results of any validation studies. The information is structured according to the OECD validation principles.
ReadEDTest	https://readedtest.u-paris-sciences.fr/	Tool to assess the readiness of in vitro test methods
RE-Place database	https://www.re-place.be/database	Collects the available NAMs in one central database
Systemic and Topical chemical Toxicity (STopTox)	https://stoptox.mml.unc.edu/	Tool (computational models) available as an alternative method for assessing the potential of chemicals to cause acute toxicity
TG-GATEs	https://www.toxicodb.ca/datasets/1	Toxicogenomics database (Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System)
Tox21BodyMap	https://sandbox.ntp.niehs.nih.gov/bodymap/	Webtool allowing a user to identify target organs in the human body where a substance is estimated to be more likely to produce effects
TK-Plate	https://doi.org/10.2903/j.efsa.2023.e211101	EFSA open-source platform that integrates physiologically-based kinetic (PBK), physiologically-based kinetic dynamic (PBKD), toxicokinetic-toxicodynamic (TK-TD) for humans and food-producing animals
ToxCast	https://comptox.epa.gov/dashboard/chemical-lists/toxcast	Full list of chemicals having undergone some level of screening in EPA's ToxCast research program from 2007 to the present