| Toxicokinetics, metabolism and distribution |
| In vitro |
OECD TG 428: Skin Absorption: In Vitro Method |
23 Nov 2004 |
| Acute Toxicity* |
| N/A |
N/A |
N/A |
| Skin irritation / corrosion |
| In vitro |
OECD TG 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method |
17 Jun 2021 |
| In vitro |
OECD TG 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method |
18 Jun 2019 |
| In vitro |
OECD TG 435: In Vitro Membrane Barrier Test Method for Skin Corrosion |
28 Jul 2015 |
| In vitro |
OECD TG 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER) |
28 Jul 2015 |
| Eye irritation |
| In vitro |
OECD TG 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage |
04 Jul 2023 |
| In vitro |
OECD TG 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage) |
04 Jul 2023 |
| In vitro |
OECD TG 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage |
04 Jul 2023 |
| In vitro |
OECD TG 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification |
30 Jun 2022 |
| In vitro |
OECD TG 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage |
17 Jun 2021 |
| In vitro |
OECD TG 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants |
04 Jul 2023 |
| In vitro / Ex vivo |
OECD TG 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage |
04 Jul 2023 |
| In vitro / Ex vivo |
OECD TG 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage |
04 Jul 2023 |
| DA |
OECD TG 467: Defined Approaches for Serious Eye Damage and Eye Irritation |
30 Jun 2022 |
| Sensitisation |
| In Chemico |
OECD TG 442C: In Chemico Skin Sensitisation |
04 Jul 2023 |
| In vitro |
OECD TG 442D: In Vitro Skin Sensitisation |
30 Jun 2022 |
| In vitro |
OECD TG 442E: In Vitro Skin Sensitisation |
04 Jul 2023 |
| DA |
OECD TG 497: Defined Approaches on Skin Sensitisation |
04 Jul 2023 |
| Repeated dose toxicity |
| N/A |
N/A |
N/A |
| Genetic toxicity |
| In vitro |
OECD TG 471: Bacterial Reverse Mutation Test |
29 Jun 2020 |
| In vitro |
OECD TG 487: In Vitro Mammalian Cell Micronucleus Test |
04 Jul 2023 |
| In vitro |
OECD TG 473: In Vitro Mammalian Chromosomal Aberration Test |
29 Jul 2016 |
| In vitro |
OECD TG 483: Mammalian Spermatogonial Chromosomal Aberration Test |
29 Jul 2016 |
| In vitro |
OECD TG 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene |
29 Jul 2016 |
| In vitro |
OECD TG 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes |
29 Jul 2016 |
| In vitro |
OECD TG 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro |
23 Oct 1986 |
| In vitro |
OECD TG 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells |
23 Oct 1986 |
| Carcinogenicity** |
| N/A |
N/A |
N/A |
| Toxicity to reproduction |
| N/A |
N/A |
N/A |
| Specific investigations - Immunotoxicity |
| In vitro |
OECD TG 444A: In Vitro Immunotoxicity |
04 Jul 2023 |
| Specific investigations - Neurotoxicity |
| N/A |
N/A |
N/A |
| Specific investigations - Endocrine disruption |
| In vitro |
OECD TG 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals |
04 Jul 2023 |
| In vitro |
OECD TG 456: H295R Steroidogenesis Assay |
04 Jul 2023 |
| In vitro |
OECD TG 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists |
17 Jun 2021 |
| In vitro |
OECD TG 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity |
28 Jul 2015 |
| In vitro |
OECD TG 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists |
02 Oct 2012 |
| Specific investigations - Phototoxicity |
| In vitro |
OECD TG 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method |
04 Jul 2023 |
| In vitro |
OECD TG 495: Ros (Reactive Oxygen Species) Assay for Photoreactivity |
18 Jun 2019 |
| In vitro |
OECD TG 432: In Vitro 3T3 NRU Phototoxicity Test |
18 Jun 2019 |